The Meta CEO, 40, and Chan, 39, were seen enjoying the night, dancing together and looking affectionate throughout the event.
Zuckerberg shared several photos on Instagram, showing the couple in sparkly outfits as they smiled, kissed, and hit the dance floor. He captioned the post, “Disco queen wanted a party.”
This celebration comes shortly after Zuckerberg designed a custom Porsche minivan, the first of its kind, for Chan.
“Priscilla wanted a minivan, so I designed something I think should exist,” he wrote alongside a photo of the car.
In the past, Zuckerberg also commissioned a statue of Chan for their backyard.
The couple met at a house party during Chan’s freshman year at Harvard in 2003 and married in May 2012, just one day after Facebook’s IPO made Zuckerberg a billionaire.
They are parents to three daughters: Maxima (8), August (6), and 19-month-old Aurelia. Chan, who graduated from Harvard with a biology degree, worked as a teacher for a year before pursuing a medical career, completing her pediatric residency in 2015.
The family splits their time between homes in California and Hawaii.